/mcp© 2026 Cisco and/or its affiliates. All rights reserved. Page 2 of 34 Contents About the Documentation ................................................................................................................... 3 Change History ................................................................................................................................... 3 New and Changed Information ............................................................................................................ 3 Introduction to Supported Virtualization Environments ......................................................................... 4 VMware vSphere ESXi ............................................................................................................................................ 4 Nutanix AHV ............................................................................................................................................................. 4 Cisco NFVIS-for-UC (Network Function Virtualization Infrastructure Software) ................................................ 5 Applicable Applications and Versions ............................................................................................................... 5 Physical Hardware Categories .......................................................................................................................... 5 Unsupported Infrastructure ............................................................................................................................... 6 General Requirements ........................................................................................................................ 7 Recommended Design Workflow ...................................................................................................................... 7 In a Nutshell ............................................................................................................................................................. 8 Inter-application Compatibility .......................................................................................................................... 9 Per-Application Design .................................................................................................................................... 10 Per-Application Derive Virtual Machine (VM) count/specifications .............................................................. 11 Application/Hypervisor Compatibility ............................................................................................................. 12 VM Placement ................................................................................................................................................... 13 Required Hardware Specification .................................................................................................................... 14 Bill of Materials (BOMs) .................................................................................................................................... 15 Virtualization Requirements for VMware vSphere ESXi ...................................................................... 16 Virtualization Requirements for Cisco NFVIS-for-UC ......................................................................... 24 Virtualization Requirements for Nutanix AHV ..................................................................................... 27 Example Hardware Bill of Materials (BOMs) ...................................................................................... 29 Summary of Hardware Examples .................................................................................................................... 29 Cisco Calling Appliances ......................................................................................................................................29 Small Collaboration Design used for Hardware Examples ............................................................................ 33 Medium Collaboration Design used for Hardware Examples ........................................................................ 33 Large Collaboration Design used for Hardware Examples ............................................................................ 33